Association between sleep quality and anxiety-depression co-morbid symptoms among nursing students of medical college in Hefei City / 中国学校卫生

Objective@#To describe the prevalence and association of sleep quality and anxiety-depression co-morbid symptoms among nursing students, in order to provide a reference basis for promoting the development of nursing students mental health.@*Methods@#Using a prospective study design, baseline survey was conducted in January 2019 among a random cluster sample of 1 716 individuals in three medical universities in Hefei, Anhui Province, and a follow-up survey was conducted in October 2019, with a valid number of 1 573 individuals after matching with the baseline survey. The Pittsburgh Sleep Quality Index (PSQI) was used to assess nursing students sleep quality, and the Depression Anxiety Stress Scale (DASS-21) to assess the anxiety-depression comorbid symptoms.@*Results@#The detection rates of anxiety-depression co-morbidities among nursing students at baseline and follow-up survey were 16.9% and 18.2%, respectively, and the detection rates of poor sleep quality among nursing students at baseline and follow-up survey were 10.1% and 10.3%, respectively. The results of the binary Logistic regression model showed that baseline PSQI score were positively associated with the risk of anxiety-depression co-morbid symptoms among nursing students at baseline ( OR=1.49, 95%CI =1.40-1.59) and after nine months of follow-up ( OR=1.22, 95%CI =1.16-1.28). Furthermore, the influence of baseline sleep quality on the risk of anxiety-depression co-morbid symptoms were mainly concentrated in the five dimensions of sleep time, sleep efficiency, sleep disorders, hypnotic drugs and daytime dysfunction, and such effects of sleep time, sleep disorders and daytime dysfunction still existed in the follow-up investigation.@*Conclusion@#Poor sleep quality of nursing students can increase the risk of anxiety-depression co-morbidities. Improving sleep quality of nursing students has a positive effect on improving their mental health.

Relations between psychological quality and training in basketball players / Relações entre a qualidade psicológica e o treinamento em jogadores de basquetebol / Relaciones entre la calidad psicológica y el entrenamiento en jugadores de baloncesto

ABSTRACT Introduction Psychological monitoring and psychological intervention of basketball players has been a focus of attention in sports training. In basketball, players consume much physical energy and also much mental energy. Psychological tension and emotional changes cause basketball players to restrict their technical abilities. Objective Analyze the relationship between sport-induced mental fatigue and pre-game emotions in basketball players. Methods This paper selects 40 basketball players as research volunteers. A survey questionnaire and mathematical statistics were used to analyze the relationship between basketball players' mental fatigue, training level, and pre-game emotions. This paper analyzes the relationship between psychological quality and training level of basketball players. Results There were significant correlations between various dimensions of sport-induced mental fatigue and basketball players' pregame emotions. Basketball players' pre-game self-confidence is mainly affected by training game competence and excessive energy consumption. Conclusion The psychological quality of basketball players is significantly correlated with the level of training. Athletes should pay attention to psychological quality training in sports competitions. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.

RESUMO Introdução O acompanhamento psicológico e a intervenção psicológica dos jogadores de basquete tem sido foco de atenção no treinamento esportivo. No basquetebol, os jogadores consomem muita energia física e também muita energia mental. A tensão psicológica e as alterações emocionais fazem com que os jogadores de basquetebol restrinjam suas habilidades técnicas. Objetivo Analisar a relação entre a fadiga mental induzida pelo esporte e as emoções pré-jogo nos jogadores de basquete. Métodos Este trabalho seleciona 40 jogadores de basquetebol como voluntários de pesquisa. Utilizou-se um questionário de pesquisa e estatísticas matemáticas para analisar a relação entre a fadiga mental dos jogadores de basquetebol, o nível de treinamento e as emoções pré-jogo. Este trabalho analisa a relação entre a qualidade psicológica e o nível de treinamento dos jogadores de basquetebol. Resultados Houve correlações significativas entre as várias dimensões da fadiga mental induzida pelo esporte e a emoção no pré-jogo dos jogadores de basquete. A autoconfiança dos jogadores de basquetebol antes do jogo é afetada principalmente pela competência dos jogos de treinamento e pelo consumo excessivo de energia. Conclusão A qualidade psicológica dos jogadores de basquetebol está significativamente correlacionada com o nível de treinamento. Os atletas devem prestar atenção ao treinamento de qualidade psicológica nas competições esportivas. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento.

RESUMEN Introducción El acompañamiento psicológico y la intervención psicológica de los jugadores de baloncesto han sido objeto de atención en el entrenamiento deportivo. En el baloncesto, los jugadores consumen mucha energía física y también mucha energía mental. La tensión psicológica y los cambios emocionales hacen que los jugadores de baloncesto limiten sus habilidades técnicas. Objetivo Analizar la relación entre la fatiga mental inducida por el deporte y las emociones previas al partido en jugadores de baloncesto. Métodos Este trabajo selecciona a 40 jugadores de baloncesto como voluntarios para la investigación. Para analizar la relación entre la fatiga mental de los jugadores de baloncesto, el nivel de entrenamiento y las emociones previas al partido se utilizó un cuestionario de encuesta y estadísticas matemáticas. Este artículo analiza la relación entre la calidad psicológica y el nivel de entrenamiento de los jugadores de baloncesto. Resultados Hubo correlaciones significativas entre las diversas dimensiones de la fatiga mental inducida por el deporte y las emociones previas al partido de los jugadores de baloncesto. La autoconfianza de los jugadores de baloncesto antes del partido se ve afectada principalmente por la competencia del juego de entrenamiento y el consumo excesivo de energía. Conclusión La calidad psicológica de los jugadores de baloncesto está significativamente correlacionada con el nivel de entrenamiento. Los deportistas deben prestar atención a la calidad psicológica del entrenamiento en las competiciones deportivas. Nivel de evidencia II; Estudios terapéuticos - investigación de los resultados del tratamiento.

Bidirectional associations between cellular phone use behaviors and depressive symptoms in college students: a follow up study / 中国学校卫生

Objective@#The study aimed to describe the prevalence of mobile phone use and depressive symptoms and to examine the bidirectional associations between the two among college students, providinb evidence for mental health promotion among college students.@*Methods@#A longitudinal study with follow up at 6 month intervals was conducted in 1 135 students from 2 universities in Hefei, Anhui Province and Shangrao, Jiangxi Province who were selected between April and May 2019. The last follow up was conducted between April and May 2021 based on questionnaire survey, and 999 valid participants were obtained after matching. The self designed questionnaire was used to investigate the duration of cellular phone use and use of cellular phone functions among college students. The Self rating Questionnaire for Adolescent Problematic Mobile Phone Use (SQAPMPU) and the Patient Health Questionnaire-9 (PHQ-9) were used to assess cellular phone dependence and depressive symptoms among college students. Pearson correlation analysis was used to examine the correlation between cellular phone use behavior and depressive symptoms at baseline and 2 years later; linear regression model was used to analyze the linear association between cellular phone use behavior and depressive symptoms scores; autoregressive cross lagged model was used to analyze the bidirectional associations between cellular phone use behaviors and depressive symptoms among college students over time.@*Results@#The prevalence of mobile phone dependence and depressive symptoms among college students at baseline were 24.3% and 42.4%, respectively. The mean duration of mobile phone use among college students at baseline and the 2 year follow up were (2.84±0.90)h/d and (2.02±1.05)h/d, respectively; the mean scores of mobile phone dependence were (23.30±9.00) and (23.29±10.45), respectively; the mean scores of mobile phone function use were (30.12±6.66) and (29.12±7.27), respectively; and the mean scores of depressive symptoms were (4.51±4.76) and (2.61±4.40), respectively. Pearson correlation analysis showed there were significant positive correlations between duration of cellular phone use, cellular phone dependence, use of cellular phone functions at baseline or 2 years later and depressive symptoms 2 years later( r =0.08-0.50, P <0.05). Linear regression models showed a significant positive association between cellular phone dependence at baseline and depressive symptoms ( β=0.26, 95%CI =0.23-0.29) at baseline and 2 years later ( β=0.12, 95%CI =0.09-0.15). Autoregressive cross lagged models showed that cellular phone dependence at baseline positively predicted depressive symptoms 2 years later ( β =0.04) and depressive symptoms at baseline positively predicted cellular phone dependence 2 years later( β =0.23)( P <0.05).@*Conclusion@#There was a bidirectional association between cellular phone dependence and depressive symptoms among college students. Reducing cellular phone dependence is of positive significance for improving college students mental health.

Association between cell phone dependence and anxiety-depression co morbid symptoms among college students / 中国学校卫生

Objective@#To describe the prevalence of cell phone dependence and anxiety-depression co morbidity among college students, and to explore the association between cell phone dependence and anxiety-depression co morbidity among college students, in order to provide a reference basis for promoting the development of college students mental health.@*Methods@#Using a prospective study design, baseline survey was conducted in April-May 2019 among a random whole group sample of 1 135 individuals in two universities in Hefei, Anhui Province and Shangrao, Jiangxi Province, and a follow up survey was conducted in November 2019 among the sampled population, with a valid number of 1 110 individuals after matching with the baseline survey. The Self rating Questionnaire for Adolescent Problematic Mobile Phone Use (SQAPMPU) was used to assess college students cell phone dependence, and the Depression Anxiety Stress Self Rating Scale (DASS-21) to assess depression, anxiety, and anxiety depression co morbidity symptoms, and the self administered Health Related Behavior and Mental Health Questionnaire for College Students to report sleep duration.@*Results@#The detection rates of cell phone dependence among college students at baseline and follow up surveys were 24.5% and 27.7%, respectively, and the detection rates of anxiety symptoms, depressive symptoms, and anxiety depression co morbidities were 28.7%, 21.3%, and 18.4%, respectively. The results of the binary Logistic regression model showed that cell phone dependence was positively associated with the risk of anxiety depression co morbid symptoms among college students at baseline ( OR =5.79, 95% CI =4.06-8.24) and after six months of follow up ( OR =2.62, 95% CI =1.86-3.69) ( P <0.01). The results of the moderating effect analysis showed that sleep duration moderated the association between cell phone dependence and anxiety depression co morbidities, and the interaction term was statistically significant ( β =0.08, 0.04, P <0.01).@*Conclusion@#Cell phone dependence in college students increases the risk of depressive and anxiety co morbid symptoms, and sleep mitigates effect of cell phone dependence on depressive and anxiety co morbid symptoms in college students.

Latent classes of health risk behaviors in medical students and depressive symptoms / 中国学校卫生

Objective@#To identify the latent classes of various health risk behaviors among medical students and further analyze the correlation between different classes and depression.@*Methods@#Using the method of convenient sampling, 2 014 medical students were selected from Anhui Medical University in October 2018. Self-designed online questionnaire were used to collect demographic data, health risk behavior (including smoking, drinking, suicide, sleep disorders, mobile phone dependence and lack of exercise) and depressive symptoms. Latent Class Analysis was used to cluster individuals. Logistic regression was provided to further analyze the association between health risk behaviors and depressive symptoms for the groups.@*Results@#The health hazard behaviors of medical students could be divided into three separate classes: substance dependence group (8.4%), mobile phone dependence group (22.4%) and low-risk group (69.2%). The distribution of health risk behaviors of medical students with different gender, major, grade, only child，father s educational level，monthly living expenses, academic achievement and number of friends were statistically significant (χ 2=99.37,19.07,12.05,6.64,14.28,19.35,20.61,26.39,P<0.05). The results of Logistic regression analysis showed that after adjusting for gender, major, grade, only child, father s educational level，monthly living expenses, academic achievement and number of friends, the mobile phone dependence group was positively correlated with depressive symptoms (β=1.75, P<0.01).@*Conclusion@#Different ratent classes of health risk behaviors have different correlation with depressive symptoms in groups.It is suggested that school health workers should make individualized intervention plan for different types of health hazard behavior of medical students in the future educational activities, carry out stratified intervention, alleviate the symptoms of depression and promote the mental health of medical students.

Moderating effect of sleep quality on the relationship between problematic mobile phone use and anxiety of college students / 中国学校卫生

Objective@#To describe the prevalence of problematic mobile phone use and anxiety in college students, and explore the mediating effect of sleep quality on the relationship between problematic mobile phone use and anxiety, and to provide reference for physical and mental health promotion of college students.@*Methods@#One medical college and a comprephensive college were selected in Hefei city of Anhui Province and Shangrao City of Jiangxi Province, respectively, and a cross-sectional survey was conducted. A total of 1 135 valid questionnaires were collected. The self-rating questionnaires regarding basic information of college students, use the Self-rating Questionnaire for Adolescent Problematic Mobile Phone Use(SQAPMPU) and the Self-Rating Questionnaire for Depression-Anxiety-Stress for Adolescent Problematic Mobile Phone Use(DASS-21) was used to evaluate problematic mobile phone use and anxiety, respectively. The Pittsburgh Sleep Quality Index(PSQI) was used to evaluate sleep quality.@*Conclusion@#The detection rates of college students with problematic mobile phone use and poor sleep quality were 24.6% and 13.3%, respectively. The detection rates of college students anxiety grouped by severity were 5.1%, 23.9%. Multiple Logistic regression analysis showed a positive linear correlation between problematic mobile phone use and anxiety[OR values(95%CI) were 1.86(1.01-3.44), 4.34(3.14-5.99), P<0.01]. The results of process showed that sleep quality played a moderating role between problematic mobile phone use and anxiety(R2=0.37, F=220.52, P<0.01). Interaction term s β=0.09(P<0.05).@*Conclusion@#The prevalence of problematic mobile phone use is high in college students, and problematic mobile phone use is positively related to anxiety. Good sleep quality can alleviate the relationship between mobile phone dependence and anxiety of college students.

Mobile phone dependence and gray matter volume in college freshmen / 中国学校卫生

Objective@#This study aimed to investigate the correlation between brain gray matter volume(GMV) and MPD based on voxel-based morphometry(VBM) method.@*Methods@#By using principle of random sampling method, 566 students were recruited from 5 different majors in a certain university. An electronic questionnaire was used to collect the general situation and MPD. Moreover, 266 students were obtained high-resolution 3-dimensional T1 structure images by 3.0 T MRI based on voluntary principle. A multiple regression model with VBM8 was performed to detect GMV associated with MPD scores.@*Results@#Among the 266 participants, 81 students(30.5%) reported MPD. There were no statistical differences of MPD scores between different characteristics, such as gender, residential area, sibling and perceived family income, as well as academic performance(t/F=-1.04,0.40,-1.30,0.23,1.48,P>0.05). An inverse correlation was found between GMV of the anterior cingulate gyrus(ACC) and right fusiform gyrus(FFG) with MPD scores(FDR corrected, P<0.05), and no positive associations were found.@*Conclusion@#College students with higher severity of MPD have lower GMV of ACC and right FFG, and these results suggested that MPD was correlated with brain reward, executive control and emotional related GMV.

Psychological distress and its associated risk factors among university students

SUMMARY OBJECTIVE Psychological distress is an important mental health problem among university students. The goal of this study was to determine psychological distress and its associated risk factors among students in the Anhui province. METHODS A cross-sectional study was conducted in a sample of 1304 students. In this study, a self-administered questionnaire consisting of the general demography and General Health Questionnaire (GHQ-12) was completed. Psychological distress was assessed using the GHQ-12-item questionnaire. A dichotomous category split was imposed on the GHQ-12 for the purpose of analysis. A GHQ-12 score of 4 or higher indicated psychological distress. The data were analyzed by SPSS 20.0 system. RESULTS A total of 1304 samples were analyzed in this study. The results indicated that the education level of the father and mother was associated with the students' psychological distress (P<0.001). A significant association was found between high-intensity exercise and low-intensity exercise and psychological distress. However, no significant difference was identified between gender and psychological distress (P=0.173). CONCLUSION The education level of parents, high-intensity exercise, and low-intensity exercise were associated with psychological distress. Our results suggest that it is indispensable to raise awareness of psychological disorders and its associated risk factors among university students. Further studies are required to develop appropriate interventions for high-risk groups.

RESUMO OBJETIVO O estresse psicológico é um importante problema de saúde mental entre estudantes universitários. O objetivo deste estudo foi determinar o estresse psicológico e seus fatores de risco associados entre os estudantes na província de Anhui. MÉTODOS Um estudo transversal foi realizado entre uma amostra de 1.304 indivíduos. Nesse estudo, foi preenchido um questionário autoaplicável que consiste na demografia geral e no Questionário Geral de Saúde (GHQ-12). O problema psicológico foi avaliado utilizando o questionário GHQ de 12 itens. Uma divisão dicotômica de categoria foi imposta ao GHQ-12 para efeito de análise. Uma pontuação de quatro ou mais no GHQ-12 mostrava que um indivíduo tem problemas psicológicos. Os dados foram analisados pelo software SPSS 20.0. RESULTADOS Um total de 1.304 amostras foi analisado neste estudo. Os resultados indicaram que o nível de educação do pai e da mãe estava associado com estudantes em estresse psicológico (P<0,001). Foi encontrada uma associação significativa entre o exercício de alta intensidade e o exercício de baixa intensidade com o estresse psicológico. No entanto, não foi identificada qualquer diferença significativa entre o gênero e o estresse psicológico (P=0,173). CONCLUSÃO O nível de educação dos pais, exercícios de alta intensidade e exercícios de baixa intensidade foram associados com estresse psicológico. Nossos resultados sugerem que é indispensável aumentar a sensibilização para as perturbações psicológicas e para os fatores de risco associados aos estudantes universitários. São necessários mais estudos para desenvolver intervenções adequadas para grupos de alto risco.

Study on the relationship between physical activity and physical, mental health of college students / 中国学校卫生

Objective@#To describe physical activity (PA) level of college students, and to examine the associations between PA and physical health and depression, so as to provide evidence for health promotion of college students.@*Methods@#During June to July 2018, a cross-sectional survey was conducted among 4 624 college students from 2 universities in Anhui and Jiangxi provinces. The basic information was investigated by the questionnaire. PA was assessed by the International Physical Activity Questionnaire(IPAQ). Physical and mental health were evaluated by the 36-item Short Form Health Survey Questionnaire (SF-36) and the Center for Epidemiologic Studies Depression Scale(CES-D), respectively.Chi-square test was used to examine the differences between physical health and depression among college students with different demographic characteristics. The generalized linear model and binary logistic regression model were used to analyze the relationships between PA and physical health and depression.@*Results@#The proportion of good, medium and poor physical health were 64.5%, 31.6% and 3.9%, respectively. The detection rate of depression was 34.1%. Compared to low PA group, physical health was negatively correlated with medium PA (OR=0.78, 95%CI=0.66-0.91) and high PA(OR=0.46, 95%CI=0.38-0.56). Binary logistic regression results showed that, depression was negatively associated with medium PA (OR=0.69, 95%CI=0.59-0.82) and high PA(OR=0.66, 95%CI=0.55-0.79)(P<0.05). @*Conclusion@#There is a significant association between PA and physical health and depression. Further longitudinal studies are needed to clarify the causal relationship between PA and physical and mental health.

Analysis of the status and influencing factors of delivery food consumption in Wuhan college students / 中国学校卫生

Objective@#To explore the current situation of college students’ delivery food consumption and the related factors, and to provide reference for healthy eating behaviors among college students.@*Methods@#A random cluster sampling was used to select 2 597 student sample of various majors and grades of Wuhan University of Science and Technology. The self-made questionnaire was used to investigate the frequency and causes of college students ordering delivery food, as well as the status of nutrition knowledge, attitude and behavior. The Zung Depression Self-rating Scale (SDS) was adopted to measure the mental health status of the students, and height and weight were measured by a unified height and weight scale. Finally, the influencing factors mentioned above and consumption frequency of delivery food was analyzed.@*Results@#Among the college students,60.0% reported the habit of ordering delivery food; As for the frequency of delivery food consumption, boys were singnificantly higher than girls(OR=1.38), students of first(OR=0.48) and third grade(OR=0.61) were lower than that of fourth grade,the medicine major’s frequency was lower than the science and engineering major’s(OR=0.57), and the art major’s was higher than the science and engineering’s(OR=1.94); The frequency of students who had received relevant health education was lower than the unreceived students’(OR=0.70); Students who had better performance in the nutrition learning attitude, and those who had healthier eatting habits (OR=0.62, 0.49); Students who saving reckoned delivery food as convenient, time and tasty (OR=4.77, 4.82, 2.85); Howver, students’ BMI, the score of depression scale, nutritional knowledge score, knowledge and practical attitude,diet structure score, food packaging, price and nutritional factors showed no significant effect on the frequency of delivery food consumption (P>0.05).@*Conclusion@#It is common for college students to order delivery food. gender, grade, major, nutrition and health education background, nutritional attitude, eating habits and convenient, time-saving, tasty nature of fast food are the factors influencing the frequency of delivery food consumption.

Beverages consumption, sleep quality and depressive symptoms in Chinese university students: a latent variable mediation model / 中国学校卫生

Objective@#This study aimed to examine the mediating effects of sleep quality in the association between beverages consumption and depressive symptoms in Chinese university students, and to provide a theoretical reference for preventing and reducing depression symptoms.@*Methods@#This school-based cross-sectional survey was carried out among 4 624 university students from 2 universities in Anhui and Jiangxi provinces of China. The patient health questionnaire-9 items (PHQ-9) was used to assess depressive symptoms. The Pittsburgh sleep quality index（PSQI） was used to assess sleep quality, and a self-reported dietary frequency questionnaire was used to measure beverages consumption. The quantile regression model was used to association analysis, and the latent variable mediation model was used to analyze the mediation effect.@*Results@#The positive rates of mild, moderate, moderate to severe and severe depression in 4 624 university students were 31.4%, 7.5%, 4.1% and 2.0%, respectively. There was a significant association between the beverages consumption score, the PSQI score, and the PHQ-9 score( P <0.01). The higher the quantile of the beverage consumption and PSQI score, the greater the regression coefficient ( β ), and a significant dose-response relationship was observed( P <0.01). In the latent variable mediation model of beverages consumption associated with depressive symptoms in Chinese university students, the mediating effect value of sleep quality was 0.12, and the ratio of mediating effect to total effect was 71.3%.@*Conclusion@#Our study demonstrates that poor sleep quality partially mediates the association between beverages consumption and depressive symptoms in Chinese university students.

Comparison of the formation ability of two types of machine-made nickel-titanium instruments in simulated curved root canals / 口腔疾病防治

Objective@#To compare ProTaper Universal (PU) and M3-L instruments in preparing curved root canals and to provide a reference for clinical applications.@*Methods@#Twenty resin-simulated curved single root canals were randomly divided into two groups. Root canal preparation was performed with a PU nickel-titanium file or an M3-L nickel-titanium file. Root canal preparation time, root canal length before and after preparation and root canal deviation were recorded.@*Results@#In the M3-L group, the displacement measured at the 4th to 7th sites was less than that in the PU group (P < 0.05), but there was no significant difference between the other two groups (P > 0.05); The length of the root canal before and after root canal preparation in the M3-L group was （14.90 ± 1.92）mm and （14.57 ± 1.13）mm, respectively, and the difference between the two groups was not statistically significant (t=3.18, P=0.058). The root canal length before and after root canal preparation in the PU group was（14.53 ± 1.53）mm and （14.28 ± 1.39）mm, respectively. The difference between the two groups was not statistically significant（t=2.12,P=0.124）; The average preparation time of the M3-L group [（110.15 ± 10.43）s] was less than that in the PU group [（330.48 ± 12.62）s] (P < 0.05).@*Conclusion @#The M3-L nickel-titanium file has better central positioning ability and is less time-consuming than the PU nickel-titanium file in root canal bending preparation.

Characteristics and enhanced antioxidant activity of glycated Morchella esculenta protein isolate

Abstract Morchella esculenta (L) Pers. is a highly valued edible and medicinal fungus that remains underutilized. For this study, the effects of glycation treatment on antioxidant activity and characteristics of the M. esculenta protein isolate (MPI) were investigated via the Maillard reaction. Conjugation between MPI and xylose was proven via UV-vis, FT-IR, intrinsic fluorescence analysis, and SDS-PAGE. Amino acid analysis revealed involvement of lysine, arginine and tyrosine in MPI, forming a covalent cross-link with xylose. Differential scanning calorimetry (DSC) results showed that glycated MPI (MPIG) possesses a more favorable thermal stability compared to native MPI (MPIN), heated MPI (MPIH) and an unheated mixture of MPI and xylose (MPI-XM). MPIG exhibited significantly enhanced antioxidant activity compared to MPIN, MPIH, and MPI-XM. These results indicate MPIG can serve as a promising novel source of nutraceutical and functional ingredients that exert antioxidant activity.

Anti-inflammatory activity and chemical composition of dichloromethane extract from Piper nigrum and P. longum on permanent focal cerebral ischemia injury in rats

Abstract White pepper (Piper nigrum L.) and long pepper (Piper longum L.) belong to family Piperaceae and are commonly used as household spices and traditional medicine worldwide, specifically in China and Southeast Asia. In Traditional Chinese Hui Medicine, these herbs are widely used for treatment of stroke. Our present study investigated effects of these herbs on inflammation in rat model with cerebral ischemia. After subjecting the rats to permanent middle cerebral artery occlusion (pMCAO) for 6 h, at doses of 100 and 200 mg/kg, dichloromethane fraction from white pepper and long pepper, respectively, was intragastrically administered once a day for seven consecutive days. Cerebral cortical and hippocampal tissues were collected after seven days. Superoxide dismutase, malonaldehyde, tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and IL-6 were measured by spectrophotometer. Phytochemical profile of dichloromethane fraction was determined through HPLC. Dichloromethane fraction exhibited anti-inflammatory activity by suppressing expression or production of IL-1β, IL-6, and TNF-α. By contrast, dichloromethane fraction showed activity against pMCAO injury by reducing oxygen-free radicals through increased superoxide dismutase activity and decreased malonaldehyde level. HPLC analysis revealed piperine as major component of dichloromethane fraction. These results show that dichloromethane fraction provides protection against cerebral ischemia. The possible mechanism is related to anti-inflammatory activity and reduction in oxygen-free radicals.